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Cellosaurus LO-CD2a (CVCL_A6CS)

[Text version]
Cell line name LO-CD2a
Synonyms LO-CD2A; Lo-CD2a; LO-CD2-act; Lo-CD2-act; BTI-322
Accession CVCL_A6CS
Resource Identification Initiative To cite this cell line use: LO-CD2a (RRID:CVCL_A6CS)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); HB-11423.
Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized siplizumab (MEDI-507) therapeutic antibody.
Monoclonal antibody isotype: IgG2b, kappa.
Monoclonal antibody target: UniProtKB; P06729; Human CD2.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Hierarchy Parent: CVCL_7675 (IR983F)
Category Hybridoma
Publications

CLPUB00617
Xia H.-Z., Ravoet A.-M., Latinne D., Ninane J., De Bruyere M., Sokal G., Bazin H.
Rat monoclonal antibodies specific for human T lymphocytes.
(In book chapter) Rat hybridomas and rat monoclonal antibodies; Bazin H. (eds.); pp.309-322; CRC Press; Boca Raton; USA (1990)

PubMed=7627995; DOI=10.1007/BF01525389; PMCID=PMC11037751
Bombil F., Kints J.-P., Havaux X., Scheiff J.-M., Bazin H., Latinne D.
A rat monoclonal anti-(human CD2) and L-leucine methyl ester impacts on human/SCID mouse graft and B lymphoproliferative syndrome.
Cancer Immunol. Immunother. 40:383-389(1995)

PubMed=8757956; DOI=10.1093/intimm/8.7.1113
Latinne D., De La Parra B., Nizet Y., Cornet A., Giovino-Barry V., Monroy R.L., White-Scharf M.E., Bazin H.
An anti-CD2 mAb induces immunosuppression and hyporesponsiveness of CD2+ human T cells in vitro.
Int. Immunol. 8:1113-1119(1996)

Patent=US6849258
Bazin H., Latinne D., Kaplan R., Kieber-Emmons T., Postema C.E., White-Scharf M.E.
LO-CD2a antibody and uses thereof for inhibiting T cell activation and proliferation.
Patent number US6849258, 01-Feb-2005

Patent=US7592006
Bazin H., Latinne D.
Composition comprising the LO-CD2a antibody.
Patent number US7592006, 22-Sep-2009

Cross-references
Cell line collections (Providers) ATCC; CRL-3535
Biological sample resources ABCD; ABCD_AH427
Encyclopedic resources Wikidata; Q107115673
Entry history
Entry creation20-May-2021
Last entry update02-May-2024
Version number5