ID   SNK-6
AC   CVCL_A673
SY   SNK6
DR   cancercelllines; CVCL_A673
DR   Cosmic; 1534873
DR   Cosmic; 1542074
DR   Cosmic; 2025327
DR   Cosmic; 2390118
DR   Cosmic; 2785206
DR   GEO; GSM472006
DR   GEO; GSM3021083
DR   Progenetix; CVCL_A673
DR   Wikidata; Q54955067
RX   PubMed=11157488;
RX   PubMed=12780797;
RX   PubMed=16827800;
RX   PubMed=19194464;
RX   PubMed=21052088;
RX   PubMed=22102884;
RX   PubMed=25586472;
CC   Population: Japanese.
CC   Characteristics: IL2 dependent.
CC   Sequence variation: Mutation; HGNC; HGNC:882; ATR; Unexplicit; Ex29-34del; Zygosity=Heterozygous (PubMed=16827800).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: CNV analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Nose, nasal cavity; UBERON=UBERON_0001707.
CC   Cell type: NK T-cell; CL=CL_0000814.
DI   NCIt; C4684; Nasal type extranodal NK/T-cell lymphoma
DI   ORDO; Orphanet_86879; Extranodal nasal NK/T cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   62Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 21
//
RX   PubMed=11157488; DOI=10.1182/blood.V97.3.708;
RA   Nagata H., Konno A., Kimura N., Zhang Y., Kimura M., Demachi A.,
RA   Sekine T., Yamamoto K., Shimizu N.;
RT   "Characterization of novel natural killer (NK)-cell and gammadelta
RT   T-cell lines established from primary lesions of nasal T/NK-cell
RT   lymphomas associated with the Epstein-Barr virus.";
RL   Blood 97:708-713(2001).
//
RX   PubMed=12780797; DOI=10.1046/j.1365-2141.2003.04359.x;
RA   Zhang Y., Nagata H., Ikeuchi T., Mukai H., Oyoshi M.K., Demachi A.,
RA   Morio T., Wakiguchi H., Kimura N., Shimizu N., Yamamoto K.;
RT   "Common cytological and cytogenetic features of Epstein-Barr virus
RT   (EBV)-positive natural killer (NK) cells and cell lines derived from
RT   patients with nasal T/NK-cell lymphomas, chronic active EBV infection
RT   and hydroa vacciniforme-like eruptions.";
RL   Br. J. Haematol. 121:805-814(2003).
//
RX   PubMed=16827800; DOI=10.1111/j.1349-7006.2006.00226.x; PMCID=PMC11159954;
RA   Liu A., Takakuwa T., Luo W.-J., Fujita S., Aozasa K.;
RT   "Alterations in ATR in nasal NK/T-cell lymphoma and chronic active
RT   Epstein-Barr virus infection.";
RL   Cancer Sci. 97:605-610(2006).
//
RX   PubMed=19194464; DOI=10.1038/leu.2009.3;
RA   Iqbal J., Kucuk C., Deleeuw R.J., Srivastava G., Tam W., Geng H.-M.,
RA   Klinkebiel D.L., Christman J.K., Patel K.N., Cao K., Shen L., Dybkaer K.,
RA   Tsui I.F.L., Ali H.H., Shimizu N., Au W.Y., Lam W.L., Chan W.-C.;
RT   "Genomic analyses reveal global functional alterations that promote
RT   tumor growth and novel tumor suppressor genes in natural killer-cell
RT   malignancies.";
RL   Leukemia 23:1139-1151(2009).
//
RX   PubMed=21052088; DOI=10.1038/leu.2010.255;
RA   Iqbal J., Weisenburger D.D., Chowdhury A., Tsai M.-Y., Srivastava G.,
RA   Greiner T.C., Kucuk C., Deffenbacher K.E., Vose J.M., Smith L., Au W.Y.,
RA   Nakamura S., Seto M., Delabie J., Berger F., Loong F., Ko Y.-H.,
RA   Sng I., Liu X., Loughran T.P. Jr., Armitage J.O., Chan W.-C.;
RT   "Natural killer cell lymphoma shares strikingly similar molecular
RT   features with a group of non-hepatosplenic gammadelta T-cell lymphoma
RT   and is highly sensitive to a novel aurora kinase A inhibitor in
RT   vitro.";
RG   International Peripheral T-cell Lymphoma Project;
RL   Leukemia 25:348-358(2011).
//
RX   PubMed=22102884; DOI=10.1371/journal.pone.0027271; PMCID=PMC3213120;
RA   Ramakrishnan R., Donahue H., Garcia D., Tan J., Shimizu N., Rice A.P.,
RA   Ling P.D.;
RT   "Epstein-Barr virus BART9 miRNA modulates LMP1 levels and affects
RT   growth rate of nasal NK T cell lymphomas.";
RL   PLoS ONE 6:E27271-E27271(2011).
//
RX   PubMed=25586472; DOI=10.1038/ncomms7025; PMCID=PMC7743911;
RA   Kucuk C., Jiang B., Hu X.-Z., Zhang W.-Y., Chan J.K.C., Xiao W.-M.,
RA   Lack N., Alkan C., Williams J.C., Avery K.N., Kavak P., Scuto A.,
RA   Sen E., Gaulard P., Staudt L.M., Iqbal J., Zhang W.-W., Cornish A.,
RA   Gong Q., Yang Q.-P., Sun H., d'Amore F.A., Leppa S., Liu W.-P., Fu K.,
RA   de Leval L., McKeithan T.W., Chan W.-C.;
RT   "Activating mutations of STAT5B and STAT3 in lymphomas derived from
RT   gammadelta-T or NK cells.";
RL   Nat. Commun. 6:6025.1-6025.12(2015).
//