ID   OHN-GM
AC   CVCL_A662
SY   OHNGM
DR   cancercelllines; CVCL_A662
DR   Cosmic; 787473
DR   Cosmic; 975295
DR   Cosmic; 1281350
DR   GEO; GSM2124119
DR   Progenetix; CVCL_A662
DR   Wikidata; Q54931895
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=9266938;
RX   PubMed=27750403;
RX   PubMed=29533902;
CC   Population: Japanese.
CC   Characteristics: CSF2 dependent.
CC   Doubling time: ~60 hours (PubMed=9266938).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000177881; Zygosity=Heterozygous (PubMed=27750403).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val172Phe (c.514G>T); ClinVar=VCV000428909; Zygosity=Heterozygous (PubMed=27750403).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys238Tyr (c.713G>A); ClinVar=VCV000182935; Zygosity=Heterozygous (PubMed=27750403).
CC   Omics: SNP array analysis.
CC   Donor information: Originally the patient was suffering from Hodgkin lymphoma.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3247; Myelodysplastic syndrome
DI   NCIt; C8252; Therapy-related acute myeloid leukemia
DI   ORDO; Orphanet_86846; Therapy related acute myeloid leukemia and myelodysplastic syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   60Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 17
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=9266938; DOI=10.1046/j.1365-2141.1997.2413058.x;
RA   Nagai M., Fujita M., Ikeda T., Ohmori M., Kuwabara H., Yamaoka G.,
RA   Tanaka K., Kamada N., Taniwaki M., Inoue T., Irino S., Takahara J.;
RT   "Alterations of p53 and Rb genes in a novel human GM-CSF-dependent
RT   myeloid cell line (OHN-GM) established from therapy-related
RT   leukaemia.";
RL   Br. J. Haematol. 98:392-398(1997).
//
RX   PubMed=27750403; DOI=10.1002/gcc.22430;
RA   Palau A., Mallo M., Palomo L., Rodriguez-Hernandez I., Diesch J.,
RA   Campos D., Granada I., Junca J., Drexler H.G., Sole F., Buschbeck M.;
RT   "Immunophenotypic, cytogenetic, and mutational characterization of
RT   cell lines derived from myelodysplastic syndrome patients after
RT   progression to acute myeloid leukemia.";
RL   Genes Chromosomes Cancer 56:243-252(2017).
//
RX   PubMed=29533902; DOI=10.1515/hsz-2017-0321;
RA   Drexler H.G., Pommerenke C., Eberth S., Nagel S.;
RT   "Hodgkin lymphoma cell lines: to separate the wheat from the chaff.";
RL   Biol. Chem. 399:511-523(2018).
//