ID   L-KAW
AC   CVCL_A639
DR   cancercelllines; CVCL_A639
DR   Cosmic; 721709
DR   Cosmic; 1375585
DR   IARC_TP53; 10571
DR   Wikidata; Q54900900
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=7543637;
RX   PubMed=8558913;
RX   PubMed=10071127;
CC   Population: Japanese.
CC   Doubling time: 36 hours (PubMed=7543637).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Hemizygous (PubMed=10071127).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   6Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 15
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=7543637; DOI=10.1016/0145-2126(95)00016-H;
RA   Minegishi M., Minegishi N., Yanagisawa T.-a., Tsuchiya S., Tezuka H.-a.,
RA   Kaji M., Nakamura M., Hayashi Y., Konno T.;
RT   "A human CD4- CD8- T-cell receptor alpha beta + T leukemic cell line
RT   undergoing phytohemagglutinin-induced apoptosis.";
RL   Leuk. Res. 19:433-442(1995).
//
RX   PubMed=8558913;
RA   Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M.,
RA   Imaizumi M., Endo M., Takano N., Konno T.;
RT   "Cell surface c-kit receptors in human leukemia cell lines and
RT   pediatric leukemia: selective preservation of c-kit expression on
RT   megakaryoblastic cell lines during adaptation to in vitro culture.";
RL   Leukemia 10:102-105(1996).
//
RX   PubMed=10071127; DOI=10.1016/S0145-2126(98)00146-5;
RA   Kawamura M., Ohnishi H., Guo S.-X., Sheng X.-M., Minegishi M.,
RA   Hanada R., Horibe K., Hongo T., Kaneko Y., Bessho F., Yanagisawa M.,
RA   Sekiya T., Hayashi Y.;
RT   "Alterations of the p53, p21, p16, p15 and RAS genes in childhood
RT   T-cell acute lymphoblastic leukemia.";
RL   Leuk. Res. 23:115-126(1999).
//