ID   KMO-90
AC   CVCL_A636
DR   cancercelllines; CVCL_A636
DR   Cosmic; 710458
DR   IARC_TP53; 962
DR   IARC_TP53; 3944
DR   Wikidata; Q54900128
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=7727782;
RX   PubMed=8372807;
RX   PubMed=8412323;
RX   PubMed=10637496;
CC   Population: Japanese.
CC   Doubling time: ~72 hours (PubMed=8412323).
CC   Sequence variation: Gene fusion; HGNC; HGNC:8632; PBX1 + HGNC; HGNC:11633; TCF3; Name(s)=TCF3-PBX1, E2A-PBX1 (PubMed=8412323).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro177Leu (c.530C>T); ClinVar=VCV000406583; Zygosity=Unspecified (PubMed=7727782; PubMed=8412323).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   NCIt; C80347; B acute lymphoblastic leukemia with t(1;19)(q23;p13.3) E2A-PBX1 (TCF3-PBX1)
DI   ORDO; Orphanet_585956; B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_QW97 ! KMO-R
SX   Female
AG   12Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 18
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=7727782; DOI=10.1182/blood.V85.9.2546.bloodjournal8592546;
RA   Kawamura M., Kikuchi A., Kobayashi S., Hanada R., Yamamoto K.,
RA   Horibe K., Shikano T., Ueda K., Hayashi K., Sekiya T., Hayashi Y.;
RT   "Mutations of the p53 and ras genes in childhood t(1;19)-acute
RT   lymphoblastic leukemia.";
RL   Blood 85:2546-2552(1995).
//
RX   PubMed=8372807; DOI=10.1002/ajh.2830430404;
RA   Sotomatsu M., Yugami S.-i., Shitara T., Kuroume T.;
RT   "Dipyridamole enhancement of drug sensitivity in acute lymphoblastic
RT   leukemia cells.";
RL   Am. J. Hematol. 43:251-255(1993).
//
RX   PubMed=8412323;
RA   Sotomatsu M., Hayashi Y., Kawamura M., Yugami S.-i., Shitara T.;
RT   "Establishment of a new human pre-B acute lymphoblastic leukemia cell
RT   line (KMO-90) with 1;19 translocation carrying p53 gene alterations.";
RL   Leukemia 7:1615-1620(1993).
//
RX   PubMed=10637496; DOI=10.1038/sj.leu.2401604;
RA   Drexler H.G., Fombonne S., Matsuo Y., Hu Z.-B., Hamaguchi H.,
RA   Uphoff C.C.;
RT   "p53 alterations in human leukemia-lymphoma cell lines: in
RT   vitro artifact or prerequisite for cell immortalization?";
RL   Leukemia 14:198-206(2000).
//