Cellosaurus cell line HSC-6 (CVCL

Cellosaurus HSC-6 (CVCL_A615)

Cross-references
Cell line name	HSC-6
Synonyms	HSC6
Accession	CVCL_A615
Resource Identification Initiative	To cite this cell line use: HSC-6 (RRID:CVCL_A615)
Comments	Population: Japanese.
Sequence variations	Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Unspecified (PubMed=18097548).
Disease	Oral cavity squamous cell carcinoma (NCIt: C4833) Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category	Cancer cell line
Publications	PubMed=17052259; DOI=10.1111/j.1349-7006.2006.00343.x; PMCID=PMC11160012 Kozaki K.-i., Imoto I., Pimkhaokham A., Hasegawa S., Tsuda H., Omura K., Inazawa J. PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma. Cancer Sci. 97:1351-1358(2006) PubMed=17599052; DOI=10.1038/sj.onc.1210589 Suzuki E., Imoto I., Pimkhaokham A., Nakagawa T., Kamata N., Kozaki K.-i., Amagasa T., Inazawa J. PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation. Oncogene 26:7921-7932(2007) PubMed=18097548; DOI=10.3892/ijo.32.1.101 Murugan A.K., Hong N.T., Fukui Y., Munirajan A.K., Tsuchida N. Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas. Int. J. Oncol. 32:101-111(2008)
Cell line databases/resources	cancercelllines; CVCL_A615 CGH-DB; 367-2
Encyclopedic resources	Wikidata; Q54896408
Polymorphism and mutation databases	Cosmic; 930334 Cosmic; 1046033 Cosmic; 1123042
Entry history
Entry creation	06-Jun-2012
Last entry update	19-Dec-2024
Version number	13