Cellosaurus cell line U937/EVI1 (CVCL

Cellosaurus U937/EVI1 (CVCL_A5ZK)

Cross-references
Cell line name	U937/EVI1
Accession	CVCL_A5ZK
Resource Identification Initiative	To cite this cell line use: U937/EVI1 (RRID:CVCL_A5ZK)
Comments	Population: Caucasian. Characteristics: Transduced with a MECOM/EVI1-IRES-EGFP construct. Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3498; MECOM. Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP). Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line). Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line). Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line). Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
Disease	Adult acute monocytic leukemia (NCIt: C8263) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0007 (U-937)
Sex of cell	Male
Age at sampling	37Y
Category	Cancer cell line
Publications	PubMed=21394097; DOI=10.1038/leu.2011.36 Saito Y., Nakahata S., Yamakawa N., Kaneda K., Ichihara E., Suekane A., Morishita K. CD52 as a molecular target for immunotherapy to treat acute myeloid leukemia with high EVI1 expression. Leukemia 25:921-931(2011)
Cell line databases/resources	cancercelllines; CVCL_A5ZK
Encyclopedic resources	Wikidata; Q107117183
Entry history
Entry creation	20-May-2021
Last entry update	19-Dec-2024
Version number	8