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Cellosaurus U937/EVI1 (CVCL_A5ZK)

[Text version]
Cell line name U937/EVI1
Accession CVCL_A5ZK
Resource Identification Initiative To cite this cell line use: U937/EVI1 (RRID:CVCL_A5ZK)
Comments Population: Caucasian.
Characteristics: Transduced with a MECOM/EVI1-IRES-EGFP construct.
Transfected with: HGNC; 3498; MECOM.
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line

PubMed=21394097; DOI=10.1038/leu.2011.36
Saito Y., Nakahata S., Yamakawa N., Kaneda K., Ichihara E., Suekane A., Morishita K.
CD52 as a molecular target for immunotherapy to treat acute myeloid leukemia with high EVI1 expression.
Leukemia 25:921-931(2011)

Cell line databases/resources cancercelllines; CVCL_A5ZK
Encyclopedic resources Wikidata; Q107117183
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number6