ID   AM-3
AC   CVCL_A5XS
DR   Wikidata; Q107113354
RX   PubMed=23706918;
RX   PubMed=32348439;
RX   PubMed=36452176;
CC   Population: Japanese.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1582; CCND1.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1773; CDK4 (Note=With p.Arg24Cys).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11998; TP53 (Note=With p.Met1_Ala159del).
CC   Derived from site: In situ; Bone, jaw, mandible; UBERON=UBERON_0001684.
CC   Cell type: Ameloblast; CL=CL_0000059.
DI   NCIt; C27397; Follicular ameloblastoma
DI   ORDO; Orphanet_314419; Ameloblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Telomerase immortalized cell line
DT   Created: 20-05-21; Last updated: 10-04-25; Version: 8
//
RX   PubMed=23706918; DOI=10.1016/j.oooo.2013.03.005;
RA   Kibe T., Fuchigami T., Kishida M., Iijima M., Ishihata K., Hijioka H.,
RA   Miyawaki A., Semba I., Nakamura N., Kiyono T., Kishida S.;
RT   "A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to
RT   Wnt-3a and induces osteoclastogenesis.";
RL   Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 115:780-788(2013).
//
RX   PubMed=32348439; DOI=10.1590/1678-7757-2019-0558; PMCID=PMC7185982;
RA   Fuchigami T., Suzuki H., Yoshimura T., Kibe T., Chairani E.,
RA   Kiyono T., Kishida M., Kishida S., Nakamura N.;
RT   "Ameloblastoma cell lines derived from different subtypes demonstrate
RT   distinct developmental patterns in a novel animal experimental
RT   model.";
RL   J. Appl. Oral Sci. 28:e20190558.1-e20190558.7(2020).
//
RX   PubMed=36452176; DOI=10.1016/j.mbplus.2022.100125; PMCID=PMC9703037;
RA   Bakkalci D., Abdullah Zubir A.Z., Khurram S.A., Pape J., Heikinheimo K.,
RA   Fedele S., Cheema U.;
RT   "Modelling stromal compartments to recapitulate the ameloblastoma
RT   tumour microenvironment.";
RL   Matrix Biol. Plus 16:100125.1-100125.13(2022).
//