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Cellosaurus NCI-H460/TPT10 (CVCL_A5XQ)

[Text version]
Cell line name NCI-H460/TPT10
Synonyms NCI H460/TPT10
Accession CVCL_A5XQ
Resource Identification Initiative To cite this cell line use: NCI-H460/TPT10 (RRID:CVCL_A5XQ)
Comments Population: Caucasian.
Doubling time: 22.46 +- 0.85 hours (PubMed=33425914).
Selected for resistance to: ChEBI; CHEBI_63632; Topotecan.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung large cell carcinoma (NCIt: C4450)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0459 (NCI-H460)
Children:
CVCL_A5XR (NCI-H460/TPT10 ABCG2 KO)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=33425914

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S8189,10
D7S8209
D13S31713
D16S5399
TH019.3
TPOX8
vWA17

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Publications

PubMed=33425914; DOI=10.3389/fcell.2020.607275; PMCID=PMC7786180
Lei Z.-N., Teng Q.-X., Zhang W., Fan Y.-F., Wang J.-Q., Cai C.-Y., Lu K.W., Yang D.-H., Wurpel J.N.D., Chen Z.-S.
Establishment and characterization of a topotecan resistant non-small cell lung cancer NCI-H460/TPT10 cell line.
Front. Cell Dev. Biol. 8:607275.1-607275.10(2020)

DOI=10.1158/1538-7445.AM2022-1095
Teng Q.-X., Lei Z.-N., Zhang W., Fan Y.-F., Wang J.-Q., Cai C.-Y., Yang D.-H., Wurpel J.N.D., Chen Z.-S.
Establishment and characterization of a topotecan resistant lung cancer NCI H460/TPT10 cell line and a tumor xenograft model.
Cancer Res. 82 Suppl. 12:1095-1095(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5XQ
Encyclopedic resources Wikidata; Q107116539
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number7