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Cellosaurus U-251MG PAX6-/- 2A.3 (CVCL_A5TW)

[Text version]
Cell line name U-251MG PAX6-/- 2A.3
Synonyms PAX6 2A.3 KO
Accession CVCL_A5TW
Resource Identification Initiative To cite this cell line use: U-251MG PAX6-/- 2A.3 (RRID:CVCL_A5TW)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:8620; PAX6.
Derived from site: In situ; Brain, parietal lobe; UBERON=UBERON_0001872.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu242Valfs*15 (c.723_724dupTG); ClinVar=VCV000536553; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0021 (U-251MG)
Sex of cell Male
Age at sampling 75Y
Category Cancer cell line
Publications

PubMed=29716531; DOI=10.1186/s12885-018-4394-6; PMCID=PMC5930953
Hegge B., Sjottem E., Mikkola I.
Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress.
BMC Cancer 18:496.1-496.19(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5TW
Encyclopedic resources Wikidata; Q107117154
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number7