ID   imWilms1
AC   CVCL_A5SN
SY   IM-WT-1
DR   CLS; 300412
DR   Wikidata; Q107115459
RX   PubMed=33379206;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Heterozygous (PubMed=33379206).
CC   Sequence variation: Mutation; HGNC; HGNC:12796; WT1; Simple; p.Ser50Ter (c.149C>A); Zygosity=Homozygous (PubMed=33379206).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
ST   Source(s): PubMed=33379206
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 11,13
ST   D16S539: 11,14
ST   D18S51: 15,18
ST   D21S11: 30,31
ST   D3S1358: 14,17
ST   D5S818: 12,13
ST   D7S820: 9,14
ST   D8S1179: 12,14
ST   FGA: 22,25
ST   Penta D: 13
ST   Penta E: 5,14
ST   TH01: 9.3
ST   TPOX: 8,9
ST   vWA: 14,19
DI   NCIt; C40407; Kidney Wilms tumor
DI   ORDO; Orphanet_654; Nephroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_A5SC ! Wilms1-2l
SX   Female
AG   2Y
CA   Conditionally immortalized cell line
DT   Created: 20-05-21; Last updated: 19-12-24; Version: 8
//
RX   PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943;
RA   Royer-Pokora B., Busch M.A., Tenbusch S., Schmidt M., Beier M.,
RA   Woods A.D., Thiele H., Mora J.;
RT   "Comprehensive biology and genetics compendium of Wilms tumor cell
RT   lines with different WT1 mutations.";
RL   Cancers (Basel) 13:60.1-60.21(2021).
//