Cellosaurus cell line Wilms5 (CVCL

Cellosaurus Wilms5 (CVCL_A5SH)

[Text version]

Cell line name

Wilms5

Accession

CVCL_A5SH

Resource Identification Initiative

To cite this cell line use: Wilms5 (RRID:CVCL_A5SH)

Comments

Population: Caucasian.
Donor information: The patient has a germline WT1 p.Arg390Ter (c.1168C>T) mutation that was lost in the tumor.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.

Sequence variations

Mutation; HGNC; HGNC:2514; CTNNB1; None_reported; -; Zygosity=- (PubMed=20106868; PubMed=33379206).
Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg433Profs*84 (c.1296_1299delGC); Zygosity=Homozygous; Note=Somatic (PubMed=20106868; PubMed=33379206).

Disease

Kidney Wilms tumor (NCIt: C40407)
Nephroblastoma (ORDO: Orphanet_654)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

Category

Finite cell line

STR profile

Source(s): PubMed=33379206

Markers:

Amelogenin	X,Y
CSF1PO	10,11
D3S1358	15,16
D5S818	10,13
D7S820	10
D8S1179	13,14
D13S317	11
D16S539	8,12
D18S51	12,16
D21S11	28,29
FGA	20,22
Penta D	11,13
Penta E	7,15
TH01	8
TPOX	9,10
vWA	17,18

Publications

PubMed=20106868; DOI=10.1093/hmg/ddq042
Royer-Pokora B., Busch M.A., Beier M., Duhme C., de Torres C., Mora J., Brandt A., Royer H.-D.
Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm.
Hum. Mol. Genet. 19:1651-1668(2010)

PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943
Royer-Pokora B., Busch M.A., Tenbusch S., Schmidt M., Beier M., Woods A.D., Thiele H., Mora J.
Comprehensive biology and genetics compendium of Wilms tumor cell lines with different WT1 mutations.
Cancers (Basel) 13:60.1-60.21(2021)

Cross-references

Encyclopedic resources

Wikidata; Q107117472

Entry history

Entry creation

20-May-2021

Last entry update

19-Dec-2024

Version number