Cellosaurus cell line Wilms4 (CVCL

Cellosaurus Wilms4 (CVCL_A5SG)

[Text version]

Cell line name

Wilms4

Accession

CVCL_A5SG

Resource Identification Initiative

To cite this cell line use: Wilms4 (RRID:CVCL_A5SG)

Comments

Population: Caucasian.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.

Sequence variations

Gene deletion; HGNC; HGNC:12796; WT1; Zygosity=Heterozygous (PubMed=20106868; PubMed=33379206).
Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (PubMed=20106868; PubMed=33379206).
Mutation; HGNC; HGNC:12796; WT1; Simple; p.His438Profs*7 (c.1311_1312insC); Zygosity=Heterozygous (PubMed=20106868; PubMed=33379206).

Disease

Wilms tumor-aniridia-genitourinary anomalies-mental retardation syndrome (NCIt: C3718)
WAGR syndrome (ORDO: Orphanet_893)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

11M

Category

Finite cell line

STR profile

Source(s): PubMed=33379206

Markers:

Amelogenin	X,Y
CSF1PO	10,11
D3S1358	16,17
D5S818	10,12
D7S820	10,11
D8S1179	13
D13S317	8
D16S539	9,12
D18S51	16,17
D21S11	27,31.2
FGA	20
Penta D	10,12
Penta E	11,15
TH01	7,8
TPOX	8,11
vWA	15,17

Publications

PubMed=20106868; DOI=10.1093/hmg/ddq042
Royer-Pokora B., Busch M.A., Beier M., Duhme C., de Torres C., Mora J., Brandt A., Royer H.-D.
Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm.
Hum. Mol. Genet. 19:1651-1668(2010)

PubMed=33379206; DOI=10.3390/cancers13010060; PMCID=PMC7801943
Royer-Pokora B., Busch M.A., Tenbusch S., Schmidt M., Beier M., Woods A.D., Thiele H., Mora J.
Comprehensive biology and genetics compendium of Wilms tumor cell lines with different WT1 mutations.
Cancers (Basel) 13:60.1-60.21(2021)

Cross-references

Encyclopedic resources

Wikidata; Q107117471

Entry history

Entry creation

20-May-2021

Last entry update

19-Dec-2024

Version number