Cellosaurus logo
expasy logo

Cellosaurus ARD-pUTX (CVCL_A5RZ)

[Text version]
Cell line name ARD-pUTX
Accession CVCL_A5RZ
Resource Identification Initiative To cite this cell line use: ARD-pUTX (RRID:CVCL_A5RZ)
Comments Characteristics: KDM6A/UTX expression is inducible by doxycycline (PubMed=29045832).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 12637; KDM6A.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene deletion; HGNC; 12637; KDM6A; Zygosity=Homozygous (PubMed=29045832).
  • Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5732; IGKV1-16; Name(s)=IGKV1-16-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; 5723; IGKJ5 + HGNC; 5732; IGKV1-16; Name(s)=IGKV1-16-IGKJ5 (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_XD83 (ARD)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=29045832; DOI=10.1016/j.celrep.2017.09.078; PMCID=PMC5706555
Ezponda T., Dupere-Richer D., Will C.M., Small E.C., Varghese N., Patel T., Nabet B., Popovic R., Oyer J., Bulic M., Zheng Y.-P., Huang X.-X., Shah M.Y., Maji S., Riva A., Occhionorelli M., Tonon G., Kelleher N.L., Keats J.J., Licht J.D.
UTX/KDM6A loss enhances the malignant phenotype of multiple myeloma and sensitizes cells to EZH2 inhibition.
Cell Rep. 21:628-640(2017)

Cross-references
Encyclopedic resources Wikidata; Q107113378
Gene expression databases GEO; GSM2774100
GEO; GSM2774102
GEO; GSM2774105
GEO; GSM2774107
GEO; GSM2774110
GEO; GSM2774112
GEO; GSM2774114
GEO; GSM2774117
Entry history
Entry creation20-May-2021
Last entry update10-Sep-2024
Version number5