Cellosaurus logo
expasy logo

Cellosaurus A2780/CP8 (CVCL_A5PT)

[Text version]
Cell line name A2780/CP8
Synonyms A2780(CP8); A2780CP8
Accession CVCL_A5PT
Resource Identification Initiative To cite this cell line use: A2780/CP8 (RRID:CVCL_A5PT)
Comments Population: African American.
Doubling time: 22.1 +- 0.7 hours (PubMed=3539322).
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=3539322
Behrens B.C., Hamilton T.C., Masuda H., Grotzinger K.R., Whang-Peng J., Louie K.G., Knutsen T., McKoy W.M., Young R.C., Ozols R.F.
Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues.
Cancer Res. 47:414-418(1987)

PubMed=1348364; DOI=10.1073/pnas.89.7.3070; PMCID=PMC48805
Godwin A.K., Meister A., O'Dwyer P.J., Huang C.-S., Hamilton T.C., Anderson M.E.
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.
Proc. Natl. Acad. Sci. U.S.A. 89:3070-3074(1992)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5PT
Encyclopedic resources Wikidata; Q107113316
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number7