ID   MDA-MB-231 met2
AC   CVCL_A5ER
SY   MDA-MB-231-Met2; MDA-MB-231met2
DR   BTO; BTO:0006470
DR   cancercelllines; CVCL_A5ER
DR   Wikidata; Q107116175
RX   PubMed=30337562;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Characteristics: Metastatic to lung. Established from a lung tumor after injection of the parent cell line into the tail vein of athymic nude mice (PubMed=30337562).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase (with optimized codon usage for mammalian expression).
CC   Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0062 ! MDA-MB-231
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 05-10-23; Version: 6
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RX   PubMed=30337562; DOI=10.1038/s41598-018-33453-4;
RA   Brooks H.B., Meier T.I., Geeganage S., Fales K.R., Thrasher K.J.,
RA   Konicek S.A., Spencer C.D., Thibodeaux S., Foreman R.T., Hui Y.-H.,
RA   Roth K.D., Qian Y.-W., Wang T., Luo S., Torrado A., Si C., Toth J.L.,
RA   McCowan J.R., Frimpong K., Lee M.R., Dally R.D., Shepherd T.A.,
RA   Durham T.B., Wang Y., Wu Z.-P., Iversen P.W., Njoroge F.G.;
RT   "Characterization of a novel AICARFT inhibitor which potently elevates
RT   ZMP and has anti-tumor activity in murine models.";
RL   Sci. Rep. 8:15458-15458(2018).
//