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Cellosaurus HEK293T-XRN1-null (CVCL_A5EI)

[Text version]
Cell line name HEK293T-XRN1-null
Synonyms HEK293T XRN1-null
Accession CVCL_A5EI
Resource Identification Initiative To cite this cell line use: HEK293T-XRN1-null (RRID:CVCL_A5EI)
Comments Doubling time: ~24-30 hours (DSMZ=ACC-876).
Knockout cell: Method=CRISPR/Cas9; HGNC; 30654; XRN1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 28285; Adenovirus 5.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA).
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0063 (HEK293T)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
STR profile Source(s): DSMZ=ACC-876

Markers:
AmelogeninX
CSF1PO11,12
D2S133819,20
D3S135814,15,16,17
D5S8188,9
D7S82011
D8S117911,12,13
D13S31712,14
D16S5399,13
D18S5117
D19S43316,18,19
D21S1128,30
FGA22,23,24
Penta D9,10
Penta E7,15
TH017,9.3
TPOX11
vWA16,18,19

Run an STR similarity search on this cell line
Publications

PubMed=31340047; DOI=10.1093/nar/gkz633; PMCID=PMC6753473
Chang C.-T., Muthukumar S., Weber R., Levdansky Y., Chen Y., Bhandari D., Igreja C., Wohlbold L., Valkov E., Izaurralde E.
A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5'-3' messenger RNA decay.
Nucleic Acids Res. 47:9282-9295(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-876
Cell line databases/resources DSMZCellDive; ACC-876
Encyclopedic resources Wikidata; Q107115310
Entry history
Entry creation20-May-2021
Last entry update10-Sep-2024
Version number8