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Cellosaurus HEK293T-XRN1-null (CVCL_A5EI)

[Text version]
Cell line name HEK293T-XRN1-null
Synonyms HEK293T XRN1-null
Accession CVCL_A5EI
Resource Identification Initiative To cite this cell line use: HEK293T-XRN1-null (RRID:CVCL_A5EI)
Comments Doubling time: ~24-30 hours (DSMZ=ACC-876).
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:30654; XRN1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 28285; Adenovirus 5.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA).
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0063 (HEK293T)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
STR profile Source(s): DSMZ=ACC-876

Markers:
AmelogeninX
CSF1PO11,12
D2S133819,20
D3S135814,15,16,17
D5S8188,9
D7S82011
D8S117911,12,13
D13S31712,14
D16S5399,13
D18S5117
D19S43316,18,19
D21S1128,30
FGA22,23,24
Penta D9,10
Penta E7,15
TH017,9.3
TPOX11
vWA16,18,19

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Publications

PubMed=31340047; DOI=10.1093/nar/gkz633; PMCID=PMC6753473
Chang C.-T., Muthukumar S., Weber R., Levdansky Y., Chen Y., Bhandari D., Igreja C., Wohlbold L., Valkov E., Izaurralde E.
A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5'-3' messenger RNA decay.
Nucleic Acids Res. 47:9282-9295(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-876
Cell line databases/resources DSMZCellDive; ACC-876
Encyclopedic resources Wikidata; Q107115310
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number9