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Cellosaurus HEK293 APPswe (CVCL_A5CZ)

[Text version]
Cell line name HEK293 APPswe
Synonyms HEK293-APPswe; HEK293/APPswe; 20E2
Accession CVCL_A5CZ
Resource Identification Initiative To cite this cell line use: HEK293 APPswe (RRID:CVCL_A5CZ)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:620; APP (Note=With p.Lys670Asn and p.Met671Leu).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 28285; Adenovirus 5.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0045 (HEK293)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=22842730; DOI=10.1038/aps.2012.74; PMCID=PMC4001842
Lu Q., Chen W.-Y., Zhu Z.-Y., Chen J., Xu Y.-C., Kaewpet M., Rukachaisirikul V., Chen L.-L., Shen X.
L655,240, acting as a competitive BACE1 inhibitor, efficiently decreases beta-amyloid peptide production in HEK293-APPswe cells.
Acta Pharmacol. Sin. 33:1459-1468(2012)

PubMed=29175631; DOI=10.1016/j.neulet.2017.11.052
Dai X.-L., Chang P., Li X.-X., Gao Z.-L., Sun Y.-X.
The inhibitory effect of chitosan oligosaccharides on beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells.
Neurosci. Lett. 665:80-85(2018)

Cross-references
Anatomy/cell type resources BTO; BTO_0006422
Encyclopedic resources Wikidata; Q107115302
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number6