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Cellosaurus SW1573/S1ou (CVCL_A5BE)

[Text version]
Cell line name SW1573/S1ou
Synonyms S1ou
Accession CVCL_A5BE
Resource Identification Initiative To cite this cell line use: SW1573/S1ou (RRID:CVCL_A5BE)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:472805; Ouabain.
Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:88105; Atp1a1.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser33Phe (c.98C>T); ClinVar=VCV000017583; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Lys111Glu (c.331A>G); ClinVar=VCV000376482; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11103; SMARCB1; Simple; c.362+1G>C; ClinVar=VCV000582116; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
Disease Minimally invasive lung adenocarcinoma (NCIt: C2923)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A5BA (SW1573/S1)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Publications

PubMed=1348862; DOI=10.1073/pnas.89.8.3498; PMCID=PMC48895
Eijdems E.W.H.M., Borst P., Jongsma A.P.M., de Jong S., de Vries E.G.E., van Groenigen M., Versantvoort C.H.M., Nieuwint A.W.M., Baas F.
Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype.
Proc. Natl. Acad. Sci. U.S.A. 89:3498-3502(1992)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5BE
Encyclopedic resources Wikidata; Q107116987
Entry history
Entry creation20-May-2021
Last entry update10-Sep-2024
Version number5