| Cell line name |
SW1573/S1(MRP) |
|---|
| Synonyms |
S1(MRP) |
|---|
| Accession |
CVCL_A5BC |
|---|
| Resource Identification Initiative |
To cite this cell line use: SW1573/S1(MRP) (RRID:CVCL_A5BC) |
|---|
| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 51; ABCC1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Lung; UBERON=UBERON_0002048. |
|---|
| Sequence variations |
- Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser33Phe (c.98C>T); ClinVar=VCV000017583; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Lys111Glu (c.331A>G); ClinVar=VCV000376482; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11103; SMARCB1; Simple; c.362+1G>C; ClinVar=VCV000582116; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
|
|---|
| Disease |
Minimally invasive lung adenocarcinoma (NCIt: C2923) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_A5BA (SW1573/S1) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
44Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=7809167; DOI=10.1073/pnas.91.26.13033; PMCID=PMC45575
Muller M., Meijer C., Zaman G.J.R., Borst P., Scheper R.J., Mulder N.H., de Vries E.G.E., Jansen P.L.M.
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.
Proc. Natl. Acad. Sci. U.S.A. 91:13033-13037(1994) PubMed=7644478; DOI=10.1073/pnas.92.17.7690; PMCID=PMC41211
Zaman G.J.R., Lankelma J., van Tellingen O., Beijnen J.H., Dekker H., Paulusma C.C., Oude Elferink R.P.J., Baas F., Borst P.
Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.
Proc. Natl. Acad. Sci. U.S.A. 92:7690-7694(1995) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_A5BC
|
|---|
| Encyclopedic resources |
Wikidata; Q107116983
|
|---|
| Entry history |
|---|
| Entry creation | 20-May-2021 |
|---|
| Last entry update | 10-Sep-2024 |
|---|
| Version number | 5 |
|---|
