| Cell line name |
SW1573/S1(MDR1) |
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| Synonyms |
S1(MDR1); S1(1.1); S1 1.1 |
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| Accession |
CVCL_A5BB |
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| Resource Identification Initiative |
To cite this cell line use: SW1573/S1(MDR1) (RRID:CVCL_A5BB) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28445; Vincristine (VCR).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 40; ABCB1.
Derived from site: In situ; Lung; UBERON=UBERON_0002048. |
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| Sequence variations |
- Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser33Phe (c.98C>T); ClinVar=VCV000017583; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Lys111Glu (c.331A>G); ClinVar=VCV000376482; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11103; SMARCB1; Simple; c.362+1G>C; ClinVar=VCV000582116; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
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| Disease |
Minimally invasive lung adenocarcinoma (NCIt: C2923) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_A5BA (SW1573/S1) |
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| Sex of cell |
Female |
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| Age at sampling |
44Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=1348862; DOI=10.1073/pnas.89.8.3498; PMCID=PMC48895
Eijdems E.W.H.M., Borst P., Jongsma A.P.M., de Jong S., de Vries E.G.E., van Groenigen M., Versantvoort C.H.M., Nieuwint A.W.M., Baas F.
Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype.
Proc. Natl. Acad. Sci. U.S.A. 89:3498-3502(1992) PubMed=7644478; DOI=10.1073/pnas.92.17.7690; PMCID=PMC41211
Zaman G.J.R., Lankelma J., van Tellingen O., Beijnen J.H., Dekker H., Paulusma C.C., Oude Elferink R.P.J., Baas F., Borst P.
Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.
Proc. Natl. Acad. Sci. U.S.A. 92:7690-7694(1995) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_A5BB
|
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| Encyclopedic resources |
Wikidata; Q107116982
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| Entry history |
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| Entry creation | 20-May-2021 |
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| Last entry update | 10-Sep-2024 |
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| Version number | 5 |
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