ID   GLC-4/ADRpr
AC   CVCL_A5AZ
SY   GLC4/ADRpr; GLC4-Adr2
DR   Wikidata; Q107115108
RX   PubMed=3040227;
RX   PubMed=7809167;
CC   Characteristics: Partial revertant of GLC-4/ADR obtained after culturing in drug-free medium for a number of months (3 according to PubMed=3040227 and 6 according to PubMed=7809167).
CC   Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Glu (c.394A>G); ClinVar=VCV000376626; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4997 ! GLC-4/ADR
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 19-12-24; Version: 6
//
RX   PubMed=3040227;
RA   Meijer C., Mulder N.H., Timmer-Bosscha H., Zijlstra J.G.,
RA   de Vries E.G.E.;
RT   "Role of free radicals in an adriamycin-resistant human small cell
RT   lung cancer cell line.";
RL   Cancer Res. 47:4613-4617(1987).
//
RX   PubMed=7809167; DOI=10.1073/pnas.91.26.13033; PMCID=PMC45575;
RA   Muller M., Meijer C., Zaman G.J.R., Borst P., Scheper R.J., Mulder N.H.,
RA   de Vries E.G.E., Jansen P.L.M.;
RT   "Overexpression of the gene encoding the multidrug
RT   resistance-associated protein results in increased ATP-dependent
RT   glutathione S-conjugate transport.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:13033-13037(1994).
//