Cellosaurus HepG2.105 (CVCL_A5AW)
| Cell line name | HepG2.105 |
|---|---|
| Synonyms | HepG2.TA2-7.105 |
| Accession | CVCL_A5AW |
| Resource Identification Initiative | To cite this cell line use: HepG2.105 (RRID:CVCL_A5AW) |
| Comments | Population: Caucasian. Virology: Expresses a hepatitis B virus (HBV) subtype AYW genome under the control of a tetracycline transactivator (tTA) protein, a fusion of tetR with the activation domain of HSV-1 VP16. Transcription of HBV pre-genomic RNA is induced upon doxycycline removal from the culture medium, leading to capsid assembly and DNA synthesis (PubMed=16935386). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Derived from site: In situ; Liver; UBERON=UBERON_0002107. |
| Sequence variations |
|
| Disease | Hepatoblastoma (NCIt: C3728) Hepatoblastoma (ORDO: Orphanet_449) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_0027 (Hep-G2) |
| Sex of cell | Male |
| Age at sampling | 15Y |
| Category | Cancer cell line |
| Publications | PubMed=16935386; DOI=10.1016/j.jhep.2006.05.019 |
| Cross-references | |
| Cell line databases/resources | cancercelllines; CVCL_A5AW |
| Encyclopedic resources | Wikidata; Q107115331 |
| Entry history | |
| Entry creation | 20-May-2021 |
| Last entry update | 10-Sep-2024 |
| Version number | 8 |