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Cellosaurus A2780/m248 (CVCL_A5AD)

[Text version]
Cell line name A2780/m248
Accession CVCL_A5AD
Resource Identification Initiative To cite this cell line use: A2780/m248 (RRID:CVCL_A5AD)
Comments Population: African American.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 11998; TP53 (Note=With p.Arg248Trp).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; 795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=9924699; DOI=10.1097/00002371-199901000-00007
Sleijfer S., Le T.K.P., de Jong S., Timmer-Bosscha H., Withoff S., Mulder N.H.
Combined cytotoxic effects of tumor necrosis factor-alpha with various cytotoxic agents in tumor cell lines that are drug resistant due to mutated p53.
J. Immunother. 22:48-53(1999)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5AD
Encyclopedic resources Wikidata; Q107113319
Entry history
Entry creation20-May-2021
Last entry update10-Sep-2024
Version number6