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Cellosaurus NCI-H60 (CVCL_A592)

[Text version]
Cell line name NCI-H60
Synonyms H60; H-60
Accession CVCL_A592
Resource Identification Initiative To cite this cell line use: NCI-H60 (RRID:CVCL_A592)
Comments Problematic cell line: Contaminated. Shown to be a NCI-N417 derivative.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00416.
Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (from parent cell line).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Gene fusion; HGNC; 23139; CLVS1 + HGNC; 9709; PVT1; Name(s)=PVT1-CLVS1 (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Gln546Lys (c.1636C>A); ClinVar=VCV000013657; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu298Ter (c.892G>T); ClinVar=VCV000093323; Zygosity=Unspecified (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1602 (NCI-N417)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ATCC=CRL-5821

Markers:
AmelogeninX
CSF1PO12
D5S81813
D7S82011,12
D13S31710
D16S5399
TH016
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Web pages https://www.atcc.org/en/support/technical-support/faqs/nci-h60-atcc-crl-5821
https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=6108156
Gazdar A.F., Carney D.N., Russell E.K., Sims H.L., Baylin S.B., Bunn P.A. Jr., Guccion J.G., Minna J.D.
Establishment of continuous, clonable cultures of small-cell carcinoma of lung which have amine precursor uptake and decarboxylation cell properties.
Cancer Res. 40:3502-3507(1980)

PubMed=6270685; DOI=10.1073/pnas.78.7.4591; PMCID=PMC319839
Cuttitta F., Rosen S.T., Gazdar A.F., Minna J.D.
Monoclonal antibodies that demonstrate specificity for several types of human lung cancer.
Proc. Natl. Acad. Sci. U.S.A. 78:4591-4595(1981)

PubMed=6272398; DOI=10.1126/science.6272398
Moody T.W., Pert C.B., Gazdar A.F., Carney D.N., Minna J.D.
High levels of intracellular bombesin characterize human small-cell lung carcinoma.
Science 214:1246-1248(1981)

PubMed=6713399
Rosen S.T., Mulshine J.L., Cuttitta F., Fedorko J., Carney D.N., Gazdar A.F., Minna J.D.
Analysis of human small cell lung cancer differentiation antigens using a panel of rat monoclonal antibodies.
Cancer Res. 44:2052-2061(1984)

PubMed=2985257
Carney D.N., Gazdar A.F., Bepler G., Guccion J.G., Marangos P.J., Moody T.W., Zweig M.H., Minna J.D.
Establishment and identification of small cell lung cancer cell lines having classic and variant features.
Cancer Res. 45:2913-2923(1985)

PubMed=2985258
Gazdar A.F., Carney D.N., Nau M.M., Minna J.D.
Characterization of variant subclasses of cell lines derived from small cell lung cancer having distinctive biochemical, morphological, and growth properties.
Cancer Res. 45:2924-2930(1985)

PubMed=2986243; DOI=10.1007/978-3-642-82372-5_4
Whang-Peng J., Lee E.C.
Cytogenetics of human small cell lung cancer.
Recent Results Cancer Res. 97:37-46(1985)

PubMed=1563005
Giaccone G., Battey J., Gazdar A.F., Oie H.K., Draoui M., Moody T.W.
Neuromedin B is present in lung cancer cell lines.
Cancer Res. 52:2732s-2736s(1992)

PubMed=8626706; DOI=10.1074/jbc.271.19.11477
Quinn K.A., Treston A.M., Unsworth E.J., Miller M.-J., Vos M., Grimley C., Battey J., Mulshine J.L., Cuttitta F.
Insulin-like growth factor expression in human cancer cell lines.
J. Biol. Chem. 271:11477-11483(1996)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. Suppl. 24:32-91(1996)

PubMed=8806103; DOI=10.1002/jcb.240630516
Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M., Ihde D.C., Gazdar A.F.
MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.
J. Cell. Biochem. Suppl. 24:210-217(1996)

PubMed=11030152; DOI=10.1038/sj.onc.1203815
Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)

PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084
Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.A., Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M., Aldige C.R., Wistuba I.I., Minna J.D.
From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
J. Cell. Biochem. 121:3986-3999(2020)

Cross-references
Cell line collections (Providers) ATCC; CRL-5821 - Discontinued
Cell line databases/resources cancercelllines; CVCL_A592
Anatomy/cell type resources BTO; BTO:0006541
Biological sample resources BioSample; SAMN03151862
Encyclopedic resources Wikidata; Q54908084
Gene expression databases GEO; GSM1682797
Polymorphism and mutation databases Cosmic; 1021848
Entry history
Entry creation06-Jun-2012
Last entry update02-May-2024
Version number33