ID   NCI-H838 KRAS (G12D/+9n)
AC   CVCL_A4IK
SY   KRAS (G12D/+9n) NCI-H838
DR   cancercelllines; CVCL_A4IK
DR   Horizon_Discovery; HD+114-002
DR   Wikidata; Q105510321
CC   Population: Caucasian.
CC   Characteristics: Heterozygous knockin of a KRAS activating mutation in 10 copies.
CC   Karyotypic information: Has lost chromosome Y (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11110; ARID1A; Simple; p.Pro1876Serfs*22 (c.5625_5632del) (p.CPP1657fs) (c.5621_5628delGCCCACCA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple_edited; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous; Note=By method not specified (Horizon_Discovery=HD+114-002).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu62Ter (c.184G>T); ClinVar=VCV000617472; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1594 ! NCI-H838
SX   Male
AG   59Y
CA   Cancer cell line
DT   Created: 12-01-21; Last updated: 19-12-24; Version: 8
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