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Cellosaurus THP-1 AP1-Luc2 (CVCL_A4CA)

[Text version]
Cell line name THP-1 AP1-Luc2
Accession CVCL_A4CA
Resource Identification Initiative To cite this cell line use: THP-1 AP1-Luc2 (RRID:CVCL_A4CA)
Comments Population: Japanese.
Characteristics: Stably expresses firefly luciferase under the control of the AP-1 promoter (ATCC=TIB-202-AP1-LUC2).
Doubling time: ~72 hours (ATCC=TIB-202-AP1-LUC2).
Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Firefly luciferase (Note=With optimized codon usage for mammalian expression).
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): ATCC=TIB-202-AP1-LUC2

Markers:
AmelogeninX,Y
CSF1PO11,13
D5S81811,12
D7S82010
D13S31713
D16S53911,12
TH018,9.3
TPOX8,11
vWA16

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Cross-references
Cell line collections (Providers) ATCC; TIB-202-AP1-LUC2
Cell line databases/resources cancercelllines; CVCL_A4CA
Encyclopedic resources Wikidata; Q105511185
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number8