ID   MZ-MEL-5
AC   CVCL_A468
SY   MZ-Mel-5; Mz-Mel-5; MZ MEL 5; MZ5-MEL
DR   cancercelllines; CVCL_A468
DR   Cosmic; 972269
DR   Cosmic; 2163797
DR   ESTDAB; ESTDAB-056
DR   Wikidata; Q54907226
RX   PubMed=15592718;
RX   PubMed=23851445;
CC   HLA typing: A*32:01,26:01; B*07:02,57:02; C*07:02,06:02; DPB1*04:01,04:02; DQB1*06:02,05:01; DRB1*15:01,01:01 (PubMed=15592718).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23851445).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (PubMed=23851445).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg15Lys (c.44G>A); ClinVar=VCV000404147; Zygosity=Unspecified (PubMed=23851445).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.782+1G>C; ClinVar=VCV003148166; Zygosity=Unspecified; Note=Splice donor mutation (PubMed=23851445).
ST   Source(s): ESTDAB=ESTDAB-056
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 11,12
ST   D3S1358: 16
ST   D5S818: 11
ST   D7S820: 8,13
ST   FGA: 21,25
ST   TH01: 7,9.3
ST   TPOX: 8
ST   vWA: 16,17
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 18
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RX   PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966;
RA   Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello Osuna F., Dodi I.A.,
RA   Lopez-Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G.,
RA   Garrido F.;
RT   "High frequency of homozygosity of the HLA region in melanoma cell
RT   lines reveals a pattern compatible with extensive loss of
RT   heterozygosity.";
RL   Cancer Immunol. Immunother. 54:141-148(2005).
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RX   PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006;
RA   Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L.,
RA   Borg A., Pawelec G., Guldberg P.;
RT   "Mutual exclusivity analysis of genetic and epigenetic drivers in
RT   melanoma identifies a link between p14 ARF and RARbeta signaling.";
RL   Mol. Cancer Res. 11:1166-1178(2013).
//