ID   THP-5
AC   CVCL_A441
SY   Tohoku Hospital Pediatrics-5
DR   Cosmic; 1037729
DR   Wikidata; Q54972354
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=6232734;
RX   PubMed=8558913;
RX   PubMed=29786757;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Doubling time: 42 hours (PubMed=6232734).
CC   Sequence variation: Mutation; HGNC; HGNC:7978; NR3C1; Simple; p.Ser377Leufs*5 (c.1129del); Zygosity=Heterozygous (PubMed=35124168).
CC   Sequence variation: Mutation; HGNC; HGNC:12766; NSD2; Simple; p.Lys361Gln (c.1081A>C); ClinVar=VCV001088249; Zygosity=Heterozygous (PubMed=35124168).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   13Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 12
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=6232734; DOI=10.1620/tjem.142.51;
RA   Imaizumi M., Tsuchiya S., Kobayashi Y., Yamaguchi Y., Minegishi M.,
RA   Tamura M., Konno T., Tada K.;
RT   "An Ia-like antigen positive null cell leukemia cell line (THP-5)
RT   lacking in the stimulating capacity in autologous and allogeneic mixed
RT   lymphocyte reaction.";
RL   Tohoku J. Exp. Med. 142:51-58(1984).
//
RX   PubMed=8558913;
RA   Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M.,
RA   Imaizumi M., Endo M., Takano N., Konno T.;
RT   "Cell surface c-kit receptors in human leukemia cell lines and
RT   pediatric leukemia: selective preservation of c-kit expression on
RT   megakaryoblastic cell lines during adaptation to in vitro culture.";
RL   Leukemia 10:102-105(1996).
//
RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H.,
RA   Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T.,
RA   Sugita K., Hosoi H.;
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//