Cellosaurus logo
expasy logo

Cellosaurus KOPN-63 (CVCL_A333)

[Text version]
Cell line name KOPN-63
Synonyms Kopn-63; KOPN63; Kopn63
Accession CVCL_A333
Resource Identification Initiative To cite this cell line use: KOPN-63 (RRID:CVCL_A333)
Comments Population: Japanese.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B acute lymphoblastic leukemia with t(1;19)(q23;p13.3) E2A-PBX1 (TCF3-PBX1) (NCIt: C80347)
B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3) (ORDO: Orphanet_585956)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling 12Y
Category Cancer cell line
Publications

PubMed=8289498
Wada H., Asada M., Nakazawa S., Itoh H., Kobayashi Y., Inoue T., Fukumuro K., Chan L.C., Sugita K., Hanada R., Akuta N., Kobayashi N., Mizutani S.
Clonal expansion of p53 mutant cells in leukemia progression in vitro.
Leukemia 8:53-59(1994)

PubMed=10360377; DOI=10.1038/sj.leu.2401437
Nakamura M., Sugita K., Inukai T., Goi K., Iijima K., Tezuka T., Kojika S., Shiraishi K., Miyamoto N., Karakida N., Kagami K., Koyama-Okazaki T., Mori T., Nakazawa S.
p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation.
Leukemia 13:884-890(1999)

PubMed=10490826; DOI=10.1038/sj.onc.1202874
Fu X.-Y., McGrath S., Pasillas M., Nakazawa S., Kamps M.P.
EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1.
Oncogene 18:4920-4929(1999)

PubMed=10995006; DOI=10.1038/sj.leu.2401893
Iijima K., Sugita K., Inukai T., Goi K., Tezuka T., Uno K., Sato H., Kagami K., Nakazawa S.
Expression of thrombopoietin receptor and its functional role in human B-precursor leukemia cells with 11q23 translocation or Philadelphia chromosome.
Leukemia 14:1598-1605(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=20519628; DOI=10.1182/blood-2009-09-244673
Hirose K., Inukai T., Kikuchi J., Furukawa Y., Ikawa T., Kawamoto H., Oram S.H., Gottgens B., Kiyokawa N., Miyagawa Y., Okita H., Akahane K., Zhang X.-C., Kuroda I., Honna H., Kagami K., Goi K., Kurosawa H., Look A.T., Matsui H., Inaba T., Sugita K.
Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).
Blood 116:962-970(2010)

PubMed=20575032; DOI=10.1002/ajh.21738; PMCID=PMC7159455
Inukai T., Zhang X.-R., Kameyama T., Suzuki Y., Yoshikawa K., Kuroda I., Nemoto A., Akahane K., Sato H., Goi K., Nakamoto K., Hamada J.-i., Tada M., Moriuchi T., Sugita K.
A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines.
Am. J. Hematol. 85:535-537(2010)

PubMed=29786757; DOI=10.1007/s12185-018-2474-7
Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H., Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T., Sugita K., Hosoi H.
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Int. J. Hematol. 108:312-318(2018)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C., Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H., Minegishi M., Iwamoto S., Sugita K., Inukai T.
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A333
Encyclopedic resources Wikidata; Q54900320
Polymorphism and mutation databases IARC_TP53; 2684
IARC_TP53; 28419
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number19