Cellosaurus cell line SUP-B28 (CVCL

Cellosaurus SUP-B28 (CVCL_A316)

[Text version]

Cell line name

SUP-B28

Synonyms

AT-2; AT2

Accession

CVCL_A316

Secondary accession

CVCL_DI26

Resource Identification Initiative

To cite this cell line use: SUP-B28 (RRID:CVCL_A316)

Comments

Population: Caucasian and Pacific; Polynesian.
Doubling time: ~3 days (PubMed=12127395).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Miscellaneous: STR profile from personal communication of Ryan, Russell James Hubbard.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=34940123).
Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=34940123).
Gene fusion; HGNC; HGNC:3495; ETV6 + HGNC; HGNC:10471; RUNX1; Name(s)=ETV6-RUNX1, TEL-AML1; Note=ETV6 exon 5/RUNX1 exon 4 and RUNX1 exon 3/ETV6 exon 6 fusions (PubMed=8704231; PubMed=12127395; PubMed=34940123).
Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala146Thr (c.436G>A); ClinVar=VCV000197243; Zygosity=Heterozygous; Note=In 50% of the reads (PubMed=34940123).
Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000040468; Zygosity=Heterozygous; Note=In 3% of the reads (PubMed=34940123).

Disease

Childhood B acute lymphoblastic leukemia (NCIt: C9140)
B lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1) ETV6-RUNX1 (NCIt: C80334)
B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1) (ORDO: Orphanet_585929)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_A314 ! SUP-B26

Sex of cell

Male

Age at sampling

Category

Cancer cell line

STR profile

Source(s): Direct_author_submission

Markers:

Amelogenin	X,Y
CSF1PO	11,12
D2S1338	19,24
D3S1358	16,18
D5S818	10,12
D7S820	10
D8S1179	12,14
D13S317	10
D16S539	9,12
D18S51	12,13
D19S433	13,14
D21S11	29,33.2
FGA	20,24
TH01	9,9.3
TPOX	8,11
vWA	17

Publications

PubMed=8231254
Zhang L.Q., Downie P.A., Goodell W.R., McCabe N.R., Le Beau M.M., Morgan R., Sklar J., Raimondi S.C., Miley D., Goldberg A., Lu M.-M., Montag A., Smith S.D.
Establishment of cell lines from B-cell precursor acute lymphoblastic leukemia.
Leukemia 7:1865-1874(1993)

PubMed=8704231; DOI=10.1182/blood.V88.3.785.785
Kim D.-H., Moldwin R.L., Vignon C., Bohlander S.K., Suto Y., Giordano L., Gupta R., Fears S., Nucifora G., Rowley J.D., Smith S.D.
TEL-AML1 translocations with TEL and CDKN2 inactivation in acute lymphoblastic leukemia cell lines.
Blood 88:785-794(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=12127395; DOI=10.1016/S0165-4608(01)00655-0
Fears S., Chakrabarti S.R., Nucifora G., Rowley J.D.
Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression.
Cancer Genet. Cytogenet. 135:110-119(2002)

PubMed=34940123; DOI=10.3390/cimb43030149; PMCID=PMC8929001
Quentmeier H., Pommerenke C., Drexler H.G.
Molecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression.
Curr. Issues Mol. Biol. 43:2147-2156(2021)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_A316

Encyclopedic resources

Wikidata; Q54750826

Gene expression databases

ArrayExpress; E-MTAB-11038
ArrayExpress; E-MTAB-11039

Entry history

Entry creation

06-Jun-2012

Last entry update

10-Apr-2025

Version number