| Cell line name |
MCF-10A BRCA1 (185delAG/+) |
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| Synonyms |
BRCA1 (185delAG/+) MCF10A |
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| Accession |
CVCL_A2PT |
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| Resource Identification Initiative |
To cite this cell line use: MCF-10A BRCA1 (185delAG/+) (RRID:CVCL_A2PT) |
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| Comments |
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367. |
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| Sequence variations |
- Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 1100; BRCA1; Simple_edited; p.Glu23Valfs*17 (c.68_69delAG) (c.66_67AG[1]) (185delAG); ClinVar=VCV000017662; Zygosity=Heterozygous; Note=By homologous recombination (PubMed=21987798).
|
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0598 (MCF-10A) |
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| Sex of cell |
Female |
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| Age at sampling |
36Y |
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| Category |
Spontaneously immortalized cell line |
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| Publications | PubMed=21987798; DOI=10.1073/pnas.1110969108; PMCID=PMC3203756
Konishi H., Mohseni M., Tamaki A., Garay J.P., Croessmann S., Karnan S., Ota A., Wong H.-Y., Konishi Y., Karakas B., Tahir K., Abukhdeir A.M., Gustin J.P., Cidado J., Wang G.M., Cosgrove D., Cochran R.L., Jelovac D., Higgins M.J., Arena S., Hawkins L., Lauring J., Gross A.L., Heaphy C.M., Hosokawa Y., Gabrielson E.W., Meeker A.K., Visvanathan K., Argani P., Bachman K.E., Park B.H.
Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells.
Proc. Natl. Acad. Sci. U.S.A. 108:17773-17778(2011) |
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| Cross-references |
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| Cell line collections (Providers) |
Horizon_Discovery; HD+101-018
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| Encyclopedic resources |
Wikidata; Q105510071
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| Entry history |
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| Entry creation | 12-Jan-2021 |
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| Last entry update | 10-Sep-2024 |
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| Version number | 8 |
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