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Cellosaurus MCF-10A BRCA1 (185delAG/+) (CVCL_A2PT)

[Text version]
Cell line name MCF-10A BRCA1 (185delAG/+)
Synonyms BRCA1 (185delAG/+) MCF10A
Accession CVCL_A2PT
Resource Identification Initiative To cite this cell line use: MCF-10A BRCA1 (185delAG/+) (RRID:CVCL_A2PT)
Comments Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008359.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1100; BRCA1; Simple_edited; p.Glu23Valfs*17 (c.68_69delAG) (c.66_67AG[1]) (185delAG); ClinVar=VCV000017662; Zygosity=Heterozygous; Note=By homologous recombination (PubMed=21987798).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0598 (MCF-10A)
Sex of cell Female
Age at sampling 36Y
Category Spontaneously immortalized cell line

PubMed=21987798; DOI=10.1073/pnas.1110969108
Konishi H., Mohseni M., Tamaki A., Garay J.P., Croessmann S., Karnan S., Ota A., Wong H.-Y., Konishi Y., Karakas B., Tahir K., Abukhdeir A.M., Gustin J.P., Cidado J., Wang G.M., Cosgrove D., Cochran R.L., Jelovac D., Higgins M.J., Arena S., Hawkins L., Lauring J., Gross A.L., Heaphy C.M., Hosokawa Y., Gabrielson E.W., Meeker A.K., Visvanathan K., Argani P., Bachman K.E., Park B.H.
Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells.
Proc. Natl. Acad. Sci. U.S.A. 108:17773-17778(2011)

Cell line collections (Providers) Horizon_Discovery; HD+101-018
Encyclopedic resources Wikidata; Q105510071
Entry history
Entry creation12-Jan-2021
Last entry update29-Jun-2023
Version number7