Cellosaurus cell line SiBBE (CVCL

Cellosaurus SiBBE (CVCL_A2HP)

Cross-references
Cell line name	SiBBE
Accession	CVCL_A2HP
Resource Identification Initiative	To cite this cell line use: SiBBE (RRID:CVCL_A2HP)
Comments	Population: Southeast Asian; Thai. Doubling time: 17 hours (PubMed=33033327). Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6. Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7. Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: Mononuclear cell; CL=CL_0000842.
Sequence variations	Mutation; HGNC; HGNC:4827; HBB; Simple; p.His3His (c.9T>C); ClinVar=VCV000193106; Zygosity=Heterozygous (PubMed=33033327). Mutation; HGNC; HGNC:4827; HBB; Simple; p.Glu27Lys (c.79G>A) (E26K); ClinVar=VCV000015161; Zygosity=Heterozygous (PubMed=33033327). Mutation; HGNC; HGNC:4827; HBB; Simple; c.315+16G>C; ClinVar=VCV000256345; Zygosity=Heterozygous (PubMed=33033327). Mutation; HGNC; HGNC:4827; HBB; Simple; c.316-185C>T; ClinVar=VCV000036316; Zygosity=Homozygous (PubMed=33033327).
Disease	Beta thalassemia (NCIt: C34375) Beta-thalassemia major (ORDO: Orphanet_231214)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Category	Transformed cell line
Publications	PubMed=33033327; DOI=10.1038/s41598-020-73991-4; PMCID=PMC7546635 Trakarnsanga K., Tipgomut C., Metheetrairut C., Wattanapanitch M., Khuhapinant A., Poldee S., Kurita R., Nakamura Y., Srisawat C., Frayne J. Generation of an immortalised erythroid cell line from haematopoietic stem cells of a haemoglobin E/beta-thalassemia patient. Sci. Rep. 10:16798-16798(2020)
Encyclopedic resources	Wikidata; Q105511084
Entry history
Entry creation	12-Jan-2021
Last entry update	19-Dec-2024
Version number	9