ID   V79-hCYP1A2-hSULT1A1
AC   CVCL_A2GY
SY   V79-CYP1A2-SULT1A1
DR   Wikidata; Q105511673
RX   PubMed=14729582;
RX   PubMed=31112310;
RX   PubMed=33035519;
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 2596; CYP1A2.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 11453; SULT1A1.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_4V39 ! V79-hCYP1A2
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 12-01-21; Last updated: 10-09-24; Version: 6
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RX   PubMed=14729582; DOI=10.1093/carcin/bgh077;
RA   Glatt H.-R., Pabel U., Meinl W., Frederiksen H., Frandsen H., Muckel E.;
RT   "Bioactivation of the heterocyclic aromatic amine
RT   2-amino-3-methyl-9H-pyrido [2,3-b]indole (MeAalphaC) in recombinant
RT   test systems expressing human xenobiotic-metabolizing enzymes.";
RL   Carcinogenesis 25:801-807(2004).
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RX   PubMed=31112310; DOI=10.1002/em.22309;
RA   Zhu N., Hu K.-Q., Li Z.-H., Chen Y.-T., Liu Y.-G.;
RT   "Micronuclei formation by promutagens in metabolism-incompetent V79
RT   cells interacting with activation-proficient cells in various
RT   experimental settings.";
RL   Environ. Mol. Mutagen. 61:224-234(2020).
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RX   PubMed=33035519; DOI=10.1016/j.cbi.2020.109283;
RA   Yu H., Li Z.-H., Yang Z.-Y., Song M.-Q., Liu Y.-G.;
RT   "1-Methylpyrene induces chromosome loss and mitotic apparatus damage
RT   in a Chinese hamster V79-derived cell line expressing both human
RT   CYP1A2 and sulfotransferase 1A1.";
RL   Chem. Biol. Interact. 332:109283.1-109283.8(2020).
//