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Cellosaurus MBA72R (CVCL_A2FZ)

[Text version]
Cell line name MBA72R
Accession CVCL_A2FZ
Resource Identification Initiative To cite this cell line use: MBA72R (RRID:CVCL_A2FZ)
Comments Selected for resistance to: ChEBI; CHEBI_91367; Barasertib-HQPA (AZD1152-HQPA).
Miscellaneous: Age/sex of donor and metastatic site from personal communication of Guida, Gabriella.
Derived from site: Metastatic; Right temple; UBERON=UBERON_8480027.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6929; MC1R; Simple; p.Val92Met (c.274G>A); ClinVar=VCV000014308; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6929; MC1R; Simple; p.Asp294His (c.880G>C); ClinVar=VCV000014307; Zygosity=Heterozygous (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A2FY (MBA72)
Sex of cell Male
Age at sampling 82Y
Category Cancer cell line
Publications

DOI=10.1186/1479-5876-12-S1-P7
Azzariti A., Porcelli L., Quatrale A.E., Sidella L., Iacobazzi R.M., Guida G., Maida I., Cocco T., Ferretta A., Strippoli S., Guida S., Tommasi S., Paradiso A., Guida M.
Barasertib: a novel approach for the treatment of metastatic melanoma.
J. Transl. Med. 12 Suppl. 1:P7-P7(2014)

PubMed=25623468; DOI=10.1186/s12967-015-0385-4; PMCID=PMC4314759
Porcelli L., Guida G., Quatrale A.E., Cocco T., Sidella L., Maida I., Iacobazzi R.M., Ferretta A., Stolfa D.A., Strippoli S., Guida S., Tommasi S., Guida M., Azzariti A.
Aurora kinase B inhibition reduces the proliferation of metastatic melanoma cells and enhances the response to chemotherapy.
J. Transl. Med. 13:26.1-26.13(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A2FZ
Encyclopedic resources Wikidata; Q105510040
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number7