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Cellosaurus RSO4 (CVCL_A2CL)

[Text version]
Cell line name RSO4
Accession CVCL_A2CL
Resource Identification Initiative To cite this cell line use: RSO4 (RRID:CVCL_A2CL)
Comments Population: Japanese.
Characteristics: IL2 dependent.
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:11920; FAS; Simple; p.His60Arg (c.179A>G); ClinVar=VCV001439236; Zygosity=Heterozygous (PubMed=12207908).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223His (c.668C>A); Zygosity=Unspecified (from parent cell line).
Disease Adult T-cell leukemia/lymphoma (NCIt: C3184)
Adult T-cell leukemia/lymphoma (ORDO: Orphanet_86875)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VN48 (SO-4)
Sex of cell Female
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=10863977; DOI=10.1034/j.1600-0609.2000.90110.x
Yamada Y., Sugahara K., Tsuruda K., Nohda K., Mori N., Hata T., Maeda T., Hayashibara T., Joh T., Honda M., Tawara M., Tomonaga M., Miyazaki Y., Kamihira S.
Lactacystin activates FLICE (caspase 8) protease and induces apoptosis in Fas-resistant adult T-cell leukemia cell lines.
Eur. J. Haematol. 64:315-322(2000)

PubMed=12207908; DOI=10.1016/S0006-291X(02)02039-9
Maeda T., Nakayama S., Yamada Y., Sugahara K., Isomoto H., Tawara M., Yamasaki R., Onimaru Y., Matsushita T., Ohzono Y., Kamihira S.
The conformational alteration of the mutated extracellular domain of Fas in an adult T cell leukemia cell line.
Biochem. Biophys. Res. Commun. 296:1251-1256(2002)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A2CL
Encyclopedic resources Wikidata; Q105510805
Polymorphism and mutation databases Cosmic; 2765438
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number8