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Cellosaurus NCI-H508 R1 Cetux (CVCL_A2CF)

[Text version]
Cell line name NCI-H508 R1 Cetux
Synonyms NCIH508 R1 Cetux
Accession CVCL_A2CF
Resource Identification Initiative To cite this cell line use: NCI-H508 R1 Cetux (RRID:CVCL_A2CF)
Comments Population: Caucasian.
Selected for resistance to: DrugBank; DB00002; Cetuximab (Erbitux).
Derived from site: Metastatic; Abdominal wall; UBERON=UBERON_0003697.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly596Arg (c.1786G>C); ClinVar=VCV000375943; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Cecum adenocarcinoma (NCIt: C5543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1564 (NCI-H508)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
Publications

PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821
Arena S., Bellosillo B., Siravegna G., Martinez A., Canadas I., Lazzari L., Ferruz N., Russo M., Misale S., Gonzalez I., Iglesias M., Gavilan E., Corti G., Hobor S., Crisafulli G., Salido M., Sanchez J., Dalmases A., Bellmunt J., De Fabritiis G., Rovira A., Di Nicolantonio F., Albanell J., Bardelli A., Montagut C.
Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer.
Clin. Cancer Res. 21:2157-2166(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A2CF
Encyclopedic resources Wikidata; Q105510315
Polymorphism and mutation databases Cosmic; 2841373
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number6