| Cell line name |
LIM1215 R1 Cetux |
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| Accession |
CVCL_A2CA |
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| Resource Identification Initiative |
To cite this cell line use: LIM1215 R1 Cetux (RRID:CVCL_A2CA) |
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| Comments |
Population: Caucasian.
Selected for resistance to: DrugBank; DB00002; Cetuximab (Erbitux).
Derived from site: Metastatic; Omentum; UBERON=UBERON_0003688. |
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| Sequence variations |
- Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Ile491Met (c.1473A>G); ClinVar=VCV001404733; Zygosity=Heterozygous; Note=Acquired during resistance selection process (PubMed=25623215).
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Pro423Gln (c.1268C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Thr41Ala (c.121A>G); ClinVar=VCV000017580; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349)
Lynch syndrome (NCIt: C8494)
Lynch syndrome (ORDO: Orphanet_144) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_2574 (LIM1215) |
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| Sex of cell |
Male |
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| Age at sampling |
34Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821
Arena S., Bellosillo B., Siravegna G., Martinez A., Canadas I., Lazzari L., Ferruz N., Russo M., Misale S., Gonzalez I., Iglesias M., Gavilan E., Corti G., Hobor S., Crisafulli G., Salido M., Sanchez J., Dalmases A., Bellmunt J., De Fabritiis G., Rovira A., Di Nicolantonio F., Albanell J., Bardelli A., Montagut C.
Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer.
Clin. Cancer Res. 21:2157-2166(2015) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_A2CA
|
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| Encyclopedic resources |
Wikidata; Q105509894
|
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| Polymorphism and mutation databases |
Cosmic; 2841367
|
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| Entry history |
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| Entry creation | 12-Jan-2021 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 7 |
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