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Cellosaurus HCA46 R2 Cetux (CVCL_A2BZ)

[Text version]
Cell line name HCA46 R2 Cetux
Synonyms HCA-46 R2 Cetux
Accession CVCL_A2BZ
Resource Identification Initiative To cite this cell line use: HCA46 R2 Cetux (RRID:CVCL_A2BZ)
Comments Selected for resistance to: DrugBank; DB00002; Cetuximab (Erbitux).
Derived from site: In situ; Colon, sigmoid; UBERON=UBERON_0001159.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ala183Ser (c.547G>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val272Alafs*33 (c.815_816delTG); Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2468 (HCA46)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821
Arena S., Bellosillo B., Siravegna G., Martinez A., Canadas I., Lazzari L., Ferruz N., Russo M., Misale S., Gonzalez I., Iglesias M., Gavilan E., Corti G., Hobor S., Crisafulli G., Salido M., Sanchez J., Dalmases A., Bellmunt J., De Fabritiis G., Rovira A., Di Nicolantonio F., Albanell J., Bardelli A., Montagut C.
Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer.
Clin. Cancer Res. 21:2157-2166(2015)

Cross-references
Encyclopedic resources Wikidata; Q105507572
Polymorphism and mutation databases Cosmic; 2841365
Entry history
Entry creation12-Jan-2021
Last entry update02-May-2024
Version number5