ID   DiFi R1 Cetux
AC   CVCL_A2BW
DR   cancercelllines; CVCL_A2BW
DR   Cosmic; 2841361
DR   Wikidata; Q105506752
RX   PubMed=25623215;
CC   Population: Caucasian.
CC   Selected for resistance to: DrugBank; DB00002; Cetuximab (Erbitux).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Glu443fs*16 (c.1328_1329delAA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Glu1151Ter (c.3451G>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Lys132Arg (c.395A>G); ClinVar=VCV000376625; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C2955; Colorectal carcinoma
DI   NCIt; C6728; Gardner syndrome
DI   ORDO; Orphanet_79665; Gardner syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6895 ! DiFi
SX   Female
AG   46Y
CA   Cancer cell line
DT   Created: 12-01-21; Last updated: 05-10-23; Version: 5
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RX   PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821;
RA   Arena S., Bellosillo B., Siravegna G., Martinez A., Canadas I.,
RA   Lazzari L., Ferruz N., Russo M., Misale S., Gonzalez I., Iglesias M.,
RA   Gavilan E., Corti G., Hobor S., Crisafulli G., Salido M., Sanchez J.,
RA   Dalmases A., Bellmunt J., De Fabritiis G., Rovira A.,
RA   Di Nicolantonio F., Albanell J., Bardelli A., Montagut C.;
RT   "Emergence of multiple EGFR extracellular mutations during cetuximab
RT   treatment in colorectal cancer.";
RL   Clin. Cancer Res. 21:2157-2166(2015).
//