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Cellosaurus CCK-81 R3 Cetux (CVCL_A2BV)

[Text version]
Cell line name CCK-81 R3 Cetux
Synonyms CCK81 R3 Cetux
Accession CVCL_A2BV
Resource Identification Initiative To cite this cell line use: CCK-81 R3 Cetux (RRID:CVCL_A2BV)
Comments Population: Japanese.
Selected for resistance to: DrugBank; DB00002; Cetuximab (Erbitux).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Cys420Arg (c.1258T>C); ClinVar=VCV000031945; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278His (c.833C>A); ClinVar=VCV000376646; Zygosity=Heterozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2873 (CCK-81)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=25623215; DOI=10.1158/1078-0432.CCR-14-2821
Arena S., Bellosillo B., Siravegna G., Martinez A., Canadas I., Lazzari L., Ferruz N., Russo M., Misale S., Gonzalez I., Iglesias M., Gavilan E., Corti G., Hobor S., Crisafulli G., Salido M., Sanchez J., Dalmases A., Bellmunt J., De Fabritiis G., Rovira A., Di Nicolantonio F., Albanell J., Bardelli A., Montagut C.
Emergence of multiple EGFR extracellular mutations during cetuximab treatment in colorectal cancer.
Clin. Cancer Res. 21:2157-2166(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A2BV
Encyclopedic resources Wikidata; Q105506591
Polymorphism and mutation databases Cosmic; 2841359
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number7