ID   Endo-kun
AC   CVCL_A2BM
SY   Endokun
DR   IARC_TP53; 28431
DR   Wikidata; Q105506829
RX   PubMed=20147975;
RX   PubMed=20519628;
RX   PubMed=20575032;
RX   PubMed=29786757;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Sequence variation: Gene fusion; HGNC; HGNC:4977; HLF + HGNC; HGNC:11633; TCF3; Name(s)=TCF3-HLF, E2A-HLF (PubMed=20147975).
DI   NCIt; C199241; B acute lymphoblastic leukemia with TCF3-HLF rearrangement
DI   ORDO; Orphanet_641375; B-lymphoblastic leukemia/lymphoma with t(17;19)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   14Y
CA   Cancer cell line
DT   Created: 12-01-21; Last updated: 19-12-24; Version: 6
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RX   PubMed=20147975; DOI=10.1038/leu.2010.8;
RA   Akahane K., Inukai T., Inaba T., Kurosawa H., Look A.T., Kiyokawa N.,
RA   Fujimoto J., Goto H., Endo M., Zhang X., Hirose K., Kuroda I.,
RA   Honna H., Kagami K., Goi K., Nakazawa S., Sugita K.;
RT   "Specific induction of CD33 expression by E2A-HLF: the first evidence
RT   for aberrant myeloid antigen expression in ALL by a fusion
RT   transcription factor.";
RL   Leukemia 24:865-869(2010).
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RX   PubMed=20519628; DOI=10.1182/blood-2009-09-244673;
RA   Hirose K., Inukai T., Kikuchi J., Furukawa Y., Ikawa T., Kawamoto H.,
RA   Oram S.H., Gottgens B., Kiyokawa N., Miyagawa Y., Okita H.,
RA   Akahane K., Zhang X.-C., Kuroda I., Honna H., Kagami K., Goi K.,
RA   Kurosawa H., Look A.T., Matsui H., Inaba T., Sugita K.;
RT   "Aberrant induction of LMO2 by the E2A-HLF chimeric transcription
RT   factor and its implication in leukemogenesis of B-precursor ALL with
RT   t(17;19).";
RL   Blood 116:962-970(2010).
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RX   PubMed=20575032; DOI=10.1002/ajh.21738; PMCID=PMC7159455;
RA   Inukai T., Zhang X.-R., Kameyama T., Suzuki Y., Yoshikawa K., Kuroda I.,
RA   Nemoto A., Akahane K., Sato H., Goi K., Nakamoto K., Hamada J.-i.,
RA   Tada M., Moriuchi T., Sugita K.;
RT   "A specific linkage between the incidence of TP53 mutations and type
RT   of chromosomal translocations in B-precursor acute lymphoblastic
RT   leukemia cell lines.";
RL   Am. J. Hematol. 85:535-537(2010).
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RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H.,
RA   Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T.,
RA   Sugita K., Hosoi H.;
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
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RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//