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Cellosaurus KCL039 (CVCL_A272)

[Text version]
Cell line name KCL039
Synonyms KCL-039
Accession CVCL_A272
Resource Identification Initiative To cite this cell line use: KCL039 (RRID:CVCL_A272)
Comments Group: Clinical grade pluripotent cell line.
From: King's College London; London; United Kingdom.
Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-14-0274.
Registration: UK Stem Cell Bank (UKSCB); C-16-017, Steering comm. appl. SCSC12-37.
Omics: Genomics; Whole exome sequencing.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Embryonic stem cell; CL=CL_0002322.
HLA typing Source: PubMed=23161805
Class I
HLA-AA*01,24
HLA-BB*35:02/83,49:01/06/08
HLA-CC*04.07
Class II
HLA-DRDRB1*3
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Blastocyst stage
Category Embryonic stem cell
Publications

PubMed=23161805; DOI=10.1002/emmm.201201973; PMCID=PMC3569650
Jacquet L., Stephenson E.L., Collins R., Patel H., Trussler J., Al-Bedaery R., Renwick P.J., Ogilvie C.M., Vaughan R., Ilic D.
Strategy for the creation of clinical grade hESC line banks that HLA-match a target population.
EMBO Mol. Med. 5:10-17(2013)

PubMed=26607962; DOI=10.1038/srep17258; PMCID=PMC4660465
Canham M.A., Van Deusen A.L., Brison D.R., De Sousa P.A., Downie J.M., Devito L.G., Hewitt Z.A., Ilic D., Kimber S.J., Moore H.D., Murray H., Kunath T.
The molecular karyotype of 25 clinical-grade human embryonic stem cell lines.
Sci. Rep. 5:17258.1-17258.13(2015)

PubMed=27345806; DOI=10.1016/j.scr.2015.12.036; PMCID=PMC4757724
Devito L.G., Wood V., Kadeva N., Cornwell G., Codognotto S., Stephenson E.L., Ilic D.
Generation of KCL039 clinical grade human embryonic stem cell line.
Stem Cell Res. 16:170-172(2016)

PubMed=28445466; DOI=10.1038/nature22312; PMCID=PMC5427175
Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C., Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G., Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A., Eggan K.C.
Human pluripotent stem cells recurrently acquire and expand dominant negative p53 mutations.
Nature 545:229-233(2017)

Cross-references
Cell line databases/resources NIHhESC; NIHhESC-14-0274
Encyclopedic resources Wikidata; Q54899687
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number22