ID   Ma-Mel-82
AC   CVCL_A217
SY   Ma-Mel_82; Ma-Mel 82; MaMel82
DR   cancercelllines; CVCL_A217
DR   Cosmic; 1846673
DR   Cosmic; 2686476
DR   GEO; GSM109089
DR   Wikidata; Q54903856
RX   PubMed=16827748;
RX   PubMed=17311103;
RX   PubMed=23348503;
RX   PubMed=24581590;
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Unspecified (PubMed=16827748; PubMed=17311103; PubMed=23348503).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   65Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 20
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RX   PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x;
RA   Hoek K.S., Schlegel N.C., Brafford P., Sucker A., Ugurel S., Kumar R.,
RA   Weber B.L., Nathanson K.L., Phillips D.J., Herlyn M., Schadendorf D.,
RA   Dummer R.;
RT   "Metastatic potential of melanomas defined by specific gene expression
RT   profiles with no BRAF signature.";
RL   Pigment Cell Res. 19:290-302(2006).
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RX   PubMed=17311103; DOI=10.1371/journal.pone.0000236; PMCID=PMC1794595;
RA   Ugurel S., Thirumaran R.K., Bloethner S., Gast A., Sucker A.,
RA   Mueller-Berghaus J., Rittgen W., Hemminki K., Becker J.C., Kumar R.,
RA   Schadendorf D.;
RT   "B-RAF and N-RAS mutations are preserved during short time in vitro
RT   propagation and differentially impact prognosis.";
RL   PLoS ONE 2:E236-E236(2007).
//
RX   PubMed=23348503; DOI=10.1126/science.1230062;
RA   Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A.,
RA   Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.;
RT   "TERT promoter mutations in familial and sporadic melanoma.";
RL   Science 339:959-961(2013).
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RX   PubMed=24581590; DOI=10.1016/j.jdermsci.2014.01.006;
RA   Gehrke S., Otsuka A., Huber R., Meier B., Kistowska M., Fenini G.,
RA   Cheng P., Dummer R., Kerl K., Contassot E., French L.E.;
RT   "Metastatic melanoma cell lines do not secrete IL-1beta but promote
RT   IL-1beta production from macrophages.";
RL   J. Dermatol. Sci. 74:167-169(2014).
//