Cellosaurus cell line Ma-Mel-74 (CVCL

Cellosaurus Ma-Mel-74 (CVCL_A210)

[Text version]

Cell line name

Ma-Mel-74

Synonyms

Ma-Mel_74; Ma-Mel 74

Accession

CVCL_A210

Resource Identification Initiative

To cite this cell line use: Ma-Mel-74 (RRID:CVCL_A210)

Comments

Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.

Sequence variations

Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Unspecified (PubMed=16827748; PubMed=17311103; PubMed=23348503).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.242_243CC>TT (-138/-139CC>TT); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).

Disease

Melanoma (NCIt: C3224)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

59Y

Category

Cancer cell line

STR profile

Source(s): ESTDAB=ESTDAB-208

Markers:

Amelogenin	X
CSF1PO	12,14
D3S1358	15
D5S818	11,13
D13S317	9,11
FGA	23,24
TH01	6,9.3
TPOX	8
vWA	14,17

Publications

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Hoek K.S., Schlegel N.C., Brafford P., Sucker A., Ugurel S., Kumar R., Weber B.L., Nathanson K.L., Phillips D.J., Herlyn M., Schadendorf D., Dummer R.
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=17311103; DOI=10.1371/journal.pone.0000236; PMCID=PMC1794595
Ugurel S., Thirumaran R.K., Bloethner S., Gast A., Sucker A., Mueller-Berghaus J., Rittgen W., Hemminki K., Becker J.C., Kumar R., Schadendorf D.
B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis.
PLoS ONE 2:E236-E236(2007)

PubMed=23348503; DOI=10.1126/science.1230062
Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_A210
ESTDAB; ESTDAB-208

Encyclopedic resources

Wikidata; Q54903849

Gene expression databases

GEO; GSM109085

Polymorphism and mutation databases

Cosmic; 1846667
Cosmic; 2647640
Cosmic; 2686469

Entry history

Entry creation

06-Jun-2012

Last entry update

19-Dec-2024

Version number