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Cellosaurus Ma-Mel-65 (CVCL_A200)

[Text version]
Cell line name Ma-Mel-65
Synonyms Ma-Mel_65; Ma-Mel 65
Accession CVCL_A200
Resource Identification Initiative To cite this cell line use: Ma-Mel-65 (RRID:CVCL_A200)
Comments Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (PubMed=16827748; PubMed=17311103; PubMed=23348503).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.204_205CC>TT (-100/101C>T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 24Y
Category Cancer cell line
STR profile Source(s): ESTDAB=ESTDAB-221

Markers:
AmelogeninX
CSF1PO10,11
D3S135815,17
D5S81812,14
D7S82010,12
D13S31711
FGA19,23
TH017
TPOX8,11
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Hoek K.S., Schlegel N.C., Brafford P., Sucker A., Ugurel S., Kumar R., Weber B.L., Nathanson K.L., Phillips D.J., Herlyn M., Schadendorf D., Dummer R.
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=17311103; DOI=10.1371/journal.pone.0000236; PMCID=PMC1794595
Ugurel S., Thirumaran R.K., Bloethner S., Gast A., Sucker A., Mueller-Berghaus J., Rittgen W., Hemminki K., Becker J.C., Kumar R., Schadendorf D.
B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis.
PLoS ONE 2:E236-E236(2007)

PubMed=23348503; DOI=10.1126/science.1230062
Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A200
ESTDAB; ESTDAB-221
Encyclopedic resources Wikidata; Q54903839
Gene expression databases GEO; GSM109079
Polymorphism and mutation databases Cosmic; 1846659
Cosmic; 2686459
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number21