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Cellosaurus RVH-421 Dab-R (CVCL_A1VM)

[Text version]
Cell line name RVH-421 Dab-R
Synonyms RVH421_Dab; RVH421 SKIN FV1; RVH421SKINFV1
Accession CVCL_A1VM
Resource Identification Initiative To cite this cell line use: RVH-421 Dab-R (RRID:CVCL_A1VM)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:75045; Dabrafenib (Tafinlar; GSK2118436).
Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (DepMap).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln52fs*71 (c.154delC); Zygosity=Heterozygous (DepMap).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1672 (RVH-421)
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line
Cross-references
Cell line databases/resources cancercelllines; CVCL_A1VM
DepMap; ACH-002461
Encyclopedic resources Wikidata; Q105510831
Entry history
Entry creation12-Jan-2021
Last entry update05-Oct-2023
Version number7