Cellosaurus cell line HT-144 Dab-R/Tram-R (CVCL

Cross-references
Cell line name	HT-144 Dab-R/Tram-R
Synonyms	HT144_Dab_Tram; HT144 SKIN FV3; HT144SKINFV3
Accession	CVCL_A1VL
Resource Identification Initiative	To cite this cell line use: HT-144 Dab-R/Tram-R (RRID:CVCL_A1VL)
Comments	Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Population: Caucasian. Selected for resistance to: ChEBI; CHEBI:75045; Dabrafenib (Tafinlar; GSK2118436). Selected for resistance to: ChEBI; CHEBI:75998; Trametinib (Mekinist; GSK1120212). Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
Sequence variations	Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Gene deletion; HGNC; 9588; PTEN; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (DepMap). Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0318 (HT-144)
Sex of cell	Male
Age at sampling	29Y
Category	Cancer cell line
Cell line databases/resources	cancercelllines; CVCL_A1VL DepMap; ACH-002459
Encyclopedic resources	Wikidata; Q105509486
Entry history
Entry creation	12-Jan-2021
Last entry update	05-Oct-2023
Version number	6