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Cellosaurus ECC3 (CVCL_A1VE)

[Text version]
Cell line name ECC3
Synonyms ICC15
Accession CVCL_A1VE
Resource Identification Initiative To cite this cell line use: ECC3 (RRID:CVCL_A1VE)
Comments Part of: Biliary tract cancer cell line atlas.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Sequence variations
  • Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Asn1718His (c.5152A>C); Zygosity=Unspecified (DepMap=ACH-001841).
  • Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Trp2788Ter (c.8363G>A); ClinVar=VCV000052564; Zygosity=Unspecified (DepMap=ACH-001841).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys141Tyr (c.422G>A); ClinVar=VCV000140801; Zygosity=Unspecified (DepMap=ACH-001841).
Disease Cholangiocarcinoma (NCIt: C4436)
Cholangiocarcinoma (ORDO: Orphanet_70567)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): DepMap=ACH-001841

Markers:
AmelogeninX,Y
CSF1PO12
D3S135817,18
D5S81813
D7S82011
D8S117910,14
D13S31713
D16S53910,12
D18S5118
D21S1131.2,32.2
FGA24,25
Penta D13
Penta E13
TH016
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=31109923; DOI=10.1158/2159-8290.CD-19-0182; PMCID=PMC6677584
Goyal L., Shi L., Liu L.Y., Fece de la Cruz F., Lennerz J.K., Raghavan S., Leschiner I., Elagina L., Siravegna G., Ng R.W.S., Vu P., Patra K.C., Saha S.K., Uppot R.N., Arellano R.S., Reyes S., Sagara T., Otsuki S., Nadres B., Shahzade H.A., Dey-Guha I., Fetter I.J., Baiev I., Van Seventer E.E., Murphy J.E., Ferrone C.R., Tanabe K.K., Deshpande V., Harding J.J., Yaeger R.D., Kelley R.K., Bardelli A., Iafrate A.J., Hahn W.C., Benes C.H., Ting D.T., Hirai H., Getz G., Juric D., Zhu A.X.-X., Corcoran R.B., Bardeesy N.M.
TAS-120 overcomes resistance to ATP-competitive FGFR inhibitors in patients with FGFR2 fusion-positive intrahepatic cholangiocarcinoma.
Cancer Discov. 9:1064-1079(2019)

PubMed=39026794; DOI=10.1101/2024.07.04.601970; PMCID=PMC11257448
Vijay V., Karisani N., Shi L., Hung Y.-H., Vu P., Kattel P., Kenney L., Merritt J., Adil R., Wu Q.-B., Zhen Y.-L., Morris R., Kreuzer J., Kathiresan M., Herrera Lopez X.I., Ellis H., Gritti I.G., Lecorgne L., Farag I., Popa A., Shen W., Kato H., Xu Q., Balasooriya E.R., Wu M.-J., Chaturantabut S., Kelley R.K., Cleary J.M., Lawrence M.S., Root D.E., Benes C.H., Deshpande V., Juric D., Sellers W.R., Ferrone C.R., Haas W., Vazquez F., Getz G., Bardeesy N.M.
Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets.
bioRxiv 2024:07.04.601970-07.04.601970(2024)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A1VE
Cell_Model_Passport; SIDM01977
DepMap; ACH-001841
Encyclopedic resources Wikidata; Q105509597
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number7