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Cellosaurus THP-1/E (CVCL_A1RT)

[Text version]
Cell line name THP-1/E
Accession CVCL_A1RT
Resource Identification Initiative To cite this cell line use: THP-1/E (RRID:CVCL_A1RT)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_4911; Etoposide (VP-16).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Publications

PubMed=2633408; DOI=10.1620/tjem.159.299
Saijo Y., Kumano N., Tokue Y., Satoh K., Oizumi K., Motomiya M.
Characterization of resistance to VP-16 in human leukemic cell line.
Tohoku J. Exp. Med. 159:299-306(1989)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A1RT
Encyclopedic resources Wikidata; Q105511202
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number6